Regulation of contraction and relaxation in arterial smooth muscle.
نویسندگان
چکیده
منابع مشابه
Regulation of contraction and relaxation in arterial smooth muscle.
Intracellular calcium concentration ([Ca2+]i)-dependent activation of myosin light chain kinase and its phosphorylation of the 20-kd light chain of myosin is generally considered the primary mechanism responsible for regulation of contractile force in arterial smooth muscle. However, recent data suggest that the relation between [Ca2+]i and myosin light chain phosphorylation is variable and dep...
متن کاملBrief Review Regulation of Contraction and Relaxation in Arterial Smooth Muscle
Intracellular calcium concentration ([Ca]i)-dependent activation of myosin light chain kinase and its phosphorylation of the 20-kd light chain of myosin is generally considered the primary mechanism responsible for regulation of contractile force in arterial smooth muscle. However, recent data suggest that the relation between [Ca], and myosin light chain phosphorylation is variable and depends...
متن کاملConcentration, and Contraction of Arterial Smooth Muscle
Na-Ca exchange is proposed to be an important regulator of myoplasmic intracellular Ca concentration ([Ca]|) and contraction in vascular smooth muscle. We investigated the role of Na-Ca exchange in regulating [Ca], in swine carotid arterial tissues that were loaded with aequorin to allow simultaneous measurement of [Ca], and force. Reversal of Na-Ca exchange, by reduction of extracellular Na co...
متن کاملMyosin phosphorylation during contraction and relaxation of tracheal smooth muscle.
The role of myosin phosphorylation in regulating smooth muscle contraction has been investigated by quantitating the myosin phosphate content of tracheal smooth muscle frozen during contraction or relaxation. Myosin was purified from quick-frozen muscle samples with the aid of antibodies prepared against tracheal smooth muscle myosin, and the phosphate content was determined after separation of...
متن کاملRegulator of Sustained Swine Arterial Smooth Muscle Contraction
Sustained smooth muscle contraction has been proposed to be regulated by either 1) sustained increases in intracellular Ca concentration ([Ca],)-dependent myosin phosphorylation or 2) diacylglycerol-dependent protein klnase C activation. We measured diacylglycerol mass with the diacylglycerol kinase assay and myoplasmic [Ca] with aequorin in swine carotid medial smooth muscle. Sustained and sig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 1992
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.20.2.129